A historical cohort study using data from medical registries in Denmark compared outcomes of neonates exposed to ondansetron to those not exposed 1: Ondansetron has been associated with a dose-related increase in the QT interval and postmarketing reports of TdP.
Ventricular arrhythmias and torsade de pointes TdP have been reported with the use of hydroxychloroquine. If ondansetron and procainamide must be coadministered, ECG monitoring is recommended. Minor Ixabepilone is a weak inhibitor of P-glycoprotein Pgp.
Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes TdP. Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering propafenone with ondansetron.
Major Due to a possible risk for QT prolongation and torsade de pointes TdPondansetron and lapatinib should be used together cautiously. Give the first dose 30 minutes prior to chemotherapy with a subsequent dose 8 hours after the initial dose.
Serotonin syndrome may occur within recommended dose ranges. Moderate Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from a few small studies indicate that ondansetron may reduce the analgesic effects of tramadol. Ondansetron has been associated with QT prolongation and postmarketing reports of TdP.
Moderate A dosage reduction of CYP2D6 substrates, such as ondansetron, may be necessary during co-administration of clobazam.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with ritonavir include ondansetron. Major Due to a possible risk for QT prolongation and torsade de pointes TdPondansetron and toremifene should be used together cautiously. Pharmacotherapy should be used as a part of a comprehensive management program that includes psychosocial support and treatment. Tizanidine administration may result in QT prolongation.
Zofran may impair your thinking or reactions. Patients with phenylketonuria should be informed that ondansetron orally disintegrating tablets ODT contain phenylalanine a component of aspartame. Sinus tachycardia is the most common arrhythmia, but other arrhythmias such as supraventricular tachycardia SVTventricular tachycardia, heart block, and premature ventricular contractions PVCs have been reported.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Minor Zonisamide is a weak inhibitor of P-glycoprotein P-gpand ondansetron is a substrate of P-gp. Be careful if you drive or do anything that requires you to be alert. Artemether; lumefantrine is associated with prolongation of the QT interval.
Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Interactions with inhibitors or inducers of these enzymes have not been reported clinically; however, the potential exists for these interactions to change the clearance and, hence, the half-life of ondansetron. Mifepristone has been associated with dose-dependent prolongation of the QT interval.