Follow all instructions closely. If a decision is made to prescribe alprazolam concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation.
Do not give Alprazolam ODT to other people, even if they have the same symptoms that you have. The administration of benzodiazepines including Alprazolam results in a cumulative effect on the CNS depression when given in combination with other psychotropic medications, antihistaminics, anticonvulsants, ethanol and other drugs that themselves cause CNS depression.
It should be assumed that alprazolam is excreted in human milk. Compounds that are potent inhibitors of CYP3A would be expected to increase plasma alprazolam concentrations. If you think there has been an overdose, call your poison control center or get medical care right away. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:.
Changes in the absorption, distribution, metabolism and excretion of benzodiazepines have been reported in a variety of disease states including alcoholism, impaired hepatic function and impaired renal function.
If adverse reactions occur at the recommended starting dose, the dose may be lowered. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
In either case, it is presumed that the prescribed dose is not sufficient to maintain plasma levels above those needed to prevent relapse, rebound or withdrawal symptoms over the entire course of the interdosing interval.
Alprazolam belongs to a class of medications called benzodiazepines. Examples of these drugs include:.
The following adverse reactions have been identified during postmarketing use of alprazolam. In addition to the associated benefits, Alprazolam also is accompanied with the side effects some of which are more common, others less common whereas some are more serious. The dose may be increased to achieve a maximum therapeutic effect, at intervals of 3 to 4 days, to a maximum daily dose of 4 mg, given in divided doses.
Cigarette smoking decreases blood levels of this medication. This document does not contain all possible drug interactions. Azole antifungal agents- Ketoconazole and itraconazole are potent CYP3A inhibitors and have been shown in vivo to increase plasma alprazolam concentrations 3.
Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine. Alprazolam orally disintegrating tablets, USP are also indicated for the treatment of panic disorder, with or without agoraphobia. Tell your healthcare provider about all the medicines you takeincluding prescription and over-the-counter medicines, vitamins, and herbal supplements.
In patients already receiving an opioid analgesic, prescribe a lower initial dose of alprazolam than indicated in the absence of an opioid and titrate based on clinical response.
For example, an anxiolytic drug may relieve dry mouth [a symptom of anxiety] in some subjects but induce dry mouth in others. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. Share on Twitter Tweet. Panic disorder has been associated with primary and secondary major depressive disorders and increased reports of suicide among untreated patients [see Warnings and Precautions, 5.