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Primidone enzyme inducer

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This process, therefore, may be associated with a number of clinical problems including higher cancer mortality, progressive AIDS, transplant rejection, and unwanted pregnancy.

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Hydroxyzine may increase the central nervous system depressant CNS depressant activities of Primidone. The risk or severity of adverse effects can be increased when Tilidine is combined with Primidone. The other metabolite, phenylethylmalonamide PEMA may or may not be anticonvulsant. The risk or severity of adverse effects can be increased when Perazine is combined with Primidone.

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There are no studies of the effects of liver disease on the pharmacokinetics of primidone. Its lack of sedating properties relative to phenobarbital and lack of somatic effects relative to phenytoin generated much interest.

The risk or severity of adverse effects can be increased when Medetomidine is combined with Primidone. Clearly, however, the presence or addition of the inducing agent—carbamazepine—substantially lowers neuroleptic plasma levels. The magnitude of this interaction may be quite pronounced. Following this, her year-old nephew, the niece's brother, was started because of family history.

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Please note that Internet Explorer version 8. SanderEpilepsy as a systemic condition: In addition, hepatic cirrhosis secondary to chronic use of primidone has been documented.

The use of primidone in renal failure is further complicated by the fact that the active metabolites, PEMA and phenobarbital, may accumulate disproportionally to the primidone.

The risk or severity of adverse effects can be increased when Mesoridazine is combined with Primidone. Mysoline primidone package insert. Archived from the original on 15 May People with epilepsy have an approximately two- to six-times greater risk of fracture than the general population Pack, In the s and s, carbamazepine and valproic acid together with the benzodiazepines became available. Primidone converts to phenobarbital and PEMA; [73] it is still unknown which exact cytochrome P enzymes are responsible.

Atracotoxins RobustoxinVersutoxin Ciguatoxins Poneratoxin.

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Primidone and barbexaclone are metabolized to phenobarbital and should be evaluated as such. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Primidone. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Primidone.

J Psychiatr Pract Enzyme-inducing AEDs increase a number of serologic markers of vascular risk, particularly cholesterol. The risk or severity of adverse effects can be increased when Propoxycaine is combined with Primidone.

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The risk or severity of adverse effects can be increased when Primidone is combined with Maprotiline.

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