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Tacrolimus and hyponatremia

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No other randomized study has been undertaken to evaluate the efficacy of any treatment modality. The patient continues to be on tacrolimus with a serum creatinine of Hyponatremia during administration of tacrolimus in an allogenic bone transplant recipient.

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The remaining 31 patients underwent autotransplantation. Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis. So there was no other cause, which could have led to hyponatremia in our patient other than tacrolimus toxicity.

Symptoms of hyponatremia included seizures in two patients and nausea and vomiting in 13 patients. Bone Marrow Transplantation 34, — The role of graft-versus-host disease in haematopoietic cell transplantation-associated glomerular disease Successful outcome using rituximab as the only immunomodulation in Pharmacokinetics of tacrolimus FK in children and adolescents with renal transplants.

Syndome of appropriate secretion of antidiuretic hormone in patients with lymphoma-associated hemophagocytic syndrome. Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus.

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Accept and close More info. So it is unlikely that the hyponatremia could be solely attributed to post-transplant polyuria.

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Higgins et al 3 showed that patients on tacrolimus were more prone to hyponatremia compared to patients receiving cyclosporine. Everolimus in immunsuppressive treatment after kidney transplantation in a patient with tubeous sclerosis: Here, we report a case of severe symptomatic hyponatremia in a renal transplant recipient on tacrolimus despite normal tacrolimus trough level.

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We use cookies to improve your experience with our site. Background Tacrolimus is a very commonly used immunosuppressive agent in renal transplantation.

Conversion to everolimus in tacrolimus-induced hyponatremia may be a good alternative immunosuppressive regimen in kidney transplant recipients with salt-losing state. This study reported severe symptomatic hyponatremia in patients, which could not be attributed to any cause other than tacrolimus.

All other potential causes of hyponatremia were ruled out in this patient. Sodium losing nephropathy and distal tubular damage of transplant kidneys with FK administration.

A recent meta-analysis concluded that data for any intervention used to improve kidney outcomes are very sparse except for short-term prednisone and that there was no evidence of benefit of prednisone in preventing serious long-term kidney disease in HSP [4].

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Further evidence for differences between cyclosporin and tacrolimus nephrotoxicities. Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK administration.

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