If the condition persists or worsens, seek medical attention. In rare instances, including when patients with severe cardiomyopathy, congestive heart failure or recent myocardial infarction were given intravenous beta-adrenergic blocking agents or disopyramide concomitantly with intravenous verapamil hydrochloride, serious adverse effects have occurred. The peak plasma concentration of norverapamil is attained approximately one and five hours after IR or SR administration, respectively.
No significant change in doxorubicin PK with intravenous verapamil administration. The dose you take and for how long will depend on your condition and should be as recommended by your doctor. Concomitant use of verapamil hydrochloride injection with agents that decrease adrenergic function may result in an exaggerated hypotensive response. The dose of dabigatran with oral verapamil may need to be reduced. Arthralgia, Muscular weakness, Myalgia. In coronary heart disease and hypertension, no correlation was found between the therapeutic effect and the plasma concentration; a definite correlation with the plasma level was determined only for the effect on the PR interval.
If you take too much overdose Immediately telephone your doctor or the Poisons Information Centre telephone 13 11 26 for advice, or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have taken too much Isoptin. Half-life values between 3 and 7 hours have been measured for the elimination of unchanged substance from the plasma after single intravenous and oral administration.
Disposal Medicines should not be disposed of via wastewater or household waste. After intravenous dosing, the mean half-life of verapamil was 9. Combined use of verapamil and colchicine is not recommended. Due to its effect on coronary vascular smooth muscle, Isoptin enhances myocardial blood flow, even in post-stenotic areas, and relieves coronary spasms.
Verapamil hydrochloride cannot be removed by haemodialysis. The addition of verapamil hydrochloride, however, has also resulted in the lowering of the serum lithium levels in patients receiving chronic stable oral lithium.
If you have not told your doctor about any of the above, tell them before you start taking Isoptin. In cases of supraventricular tachycardia the usual dose is 40 mg to mg 3 to 4 times daily according to the severity of the patient's condition.
The following measures may also be necessary:. Asystole should be handled by the usual measures including beta adrenergic stimulation e.