Comparison of efficacy of topical clindamycin and nicotinamide combination with plain clindamycin for the treatment of acne vulgaris and acne resistant to topical antibiotics Sardesai VR, Kambli VM Dept.
Group A received benzoyl peroxide 2. There is no published clinical study which compared three combinations of topical benzoyl peroxide 2.
This agent is effective as monotherapy in patients with noninflammatory or mild to moderate inflammatory acne.
Resh William, Stoughton Richard. Already a member or subscriber? At each visit patients were asked to report any adverse effect if occurred during the treatment.
Previous article Next article. Acne vulgaris and acneiform eruption. This lead on to 30 patients in each group. Antimicrob Agents Chemother ; Topical Therapy for Acne. The combination of clindamycin and tretinoin causes less irritation than tretinoin alone. Read our disclaimer for details. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris.
Similar results were obtained in the evaluation of most efficacious group among three treatment groups on mean of the number of inflammatory lesions as shown in Figure 2.
These factors include cost Table 2patient skin characteristics and types of lesions. This content is owned by the AAFP. There is dissimilarity in the combinations although clindamycin-retinoid combination is used in both the studies. In most situations, the physician does not need to look for an underlying cause of acne. Written consent was taken from every patient.
Global efficacy evaluation was evaluated based on the validated IGA, on a six point scale that is, i 0-indicating clearance of inflammatory lesions, some residual hyperpigmentation and erythema may be present; ii 1-almost clear, patients may have a few scattered comedones and fewer than five small papules; iii 2-mild severity, acne is easily recognizable, but less than half the face is involved and there are multiple comedones, papules, and pustules; iv 3-moderate severity, more than half the face is involved and there are numerous comedones, papules, and pustules; v 4-severe, the entire face is involved, covered with numerous comedones, papules, pustules, and a few nodules and cysts; vi 5-very severe, patients have high inflammatory acne covering the entire face, with nodules and cysts.
In Group B Group B containing benzoyl peroxide and nadifloxacin was found to be the most safest among all the groups as no treatment emergent dermatological adverse event occurred throughout the study.
Disorders of sebaceous glands.