Bactrim is contraindicated in pediatric patients less than 2 months of age. The disc diffusion interpretive criteria are provided in Table 1. Drugs that may affect the production of leukocytes, including sulfamethoxazole; trimethoprim, SMX-TMP, may lead to exaggerated leukopenia, especially in patients who have received a renal transplant.
Subscribe to receive email notifications whenever new articles are published. Moderate Use gemtuzumab ozogamicin and sulfamethoxazole together with caution due to the potential for additive QT interval prolongation and risk of torsade de pointes TdP. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with sulfamethoxazole; trimethoprim include ciprofloxacin.
After administration, fosaprepitant is rapidly converted to aprepitant and shares the same drug interactions. Iodine; Potassium Iodide, KI: A longer duration may be necessary with persistent or complicated infections. Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: Minor The coadministration of trimethoprim and repaglinide was found to increase the plasma concentration of repaglinide.
Major Monitor electrolytes and ECGs for QT prolongation if coadministration of sulfamethoxazole with osimertinib is necessary; an interruption of osimertinib therapy and dose reduction may be necessary if QT prolongation occurs. QT prolongation resulting in ventricular tachycardia and TdP have been reported during post-marketing use of sulfamethoxazole; trimethoprim.
Moderate Monitor for decreased efficacy of sulfamethoxazole if coadministration with enzalutamide is necessary. The Centers for Disease Control CDC mainly recommends prophylaxis only in children at risk for other opportunistic infections i.
Moderate Sulfonamides may induce hypoglycemia by increasing the secretion of insulin from the pancreas.
It was concluded that children of all ages with clinical features of HIV infection receive SMX-TMP prophylaxis in resource-poor areas, regardless of local resistance to the antibiotic. Hematologic toxicity can be increased by concurrent use of pyrimethamine.
Sulfonamides may induce hypoglycemia in some patients by increasing the secretion of insulin from the pancreas. Thus, fenoprofen may displace other highly protein bound drugs from albumin or vice versa.
Pharmacokinetics parameters for sulfamethoxazole were similar for geriatric subjects and younger adult subjects. This procedure uses paper disks impregnated with 1. Monitor for signs of phenytoin toxicity. The HIV guidelines recommend treating for 7 to 10 days or extend therapy to at least 14 days with bacteremia.
Levoleucovorin may result in the same effect. Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.
During administration of mg sulfamethoxazole and mg trimethoprim b.
Brand and Other Names: Fatalities have been documented in patients with sulfonamide hypersensitivity who receive sulfonamides, usually secondary to Stevens-Johnson syndrome, toxic epidermal necrolysis, or hepatic necrosis. Major Monitor electrolytes and ECGs for QT prolongation if coadministration of sulfamethoxazole with oxaliplatin is necessary; correct electrolyte abnormalities prior to administration of oxaliplatin.