Lopressor metoprolol is in a class of drugs known as beta blockers. It also crosses the placenta and is concentrated in breast milk; equilibrium in the placenta is attained 4 to 5 hours after dosing. If you experience anything unusual or bothersome while taking enalapril, it is important to contact your physician. Coadministration of dronedarone with a single dose of propranolol and multiple doses of metoprolol increased propranolol and metoprolol exposure by 1.
Coadministration of drugs that slow heart rate increases the risk for bradycardia. The most common side effects of metoprolol are tiredness, dizziness, depression, diarrhea, rash, and itching.
Some symptoms of low blood sugar include fast heartbeat, anxiety, chills, dizziness, drowsiness, fainting, headache, tremor, unusual sweating, vision changes and weakness.
Any changes in dosing of medications should be approved by his health care provider. Minor Estrogens can induce fluid retention and may increase blood pressure in some patients; patients who are receiving antihypertensive agents concurrently with hormonal contraceptives should be monitored for antihypertensive effectiveness. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. This is not a complete list of the side effects associated with metoprolol.
If angina markedly worsens or acute coronary insufficiency develops, promptly resume therapy, at least temporarily, and take other measures appropriate for the management of unstable angina. Careful monitoring of blood pressure and hypotensive symptoms is recommended especially in patients with ischemic heart disease and in patients on antihypertensive agents.
Extended-release metoprolol tablets are scored and may be halved; however, swallow whole or half tablet without chewing or crushing. While the combination should be used cautiously and with close monitoring, it should be noted that post-hoc analysis of amiodarone therapy in patients after acute myocardial infarction in two clinical trials revealed that amiodarone in addition to a beta-blocker significantly lowered the incidence of cardiac and arrhythmic death or resuscitated cardiac arrest when compared with amiodarone or beta-blocker therapy alone.
Patients treated concurrently with a beta-blocker and reserpine should be monitored closely for evidence of hypotension or marked bradycardia and associated symptoms e.
Here is a link to more information on metoprolol: Plasma concentrations and efficacy of metoprolol may be reduced if these drugs are administered concurrently. Moderate Concurrent use of nisoldipine with metoprolol can be beneficial i.
Potent CYP2D6 inhibitors may increase the plasma concentrations of metoprolol, resulting in similar pharmacokinetics of a patient who is a poor metabolizer of CYP2D6 isoenzymes see Pharmacokinetics. While being treated with metoprolol it is important to routinely monitor blood pressure to ensure the medication is optimally controlling your blood pressure. In general, the maximum effect of any given dosage level will be apparent after 1 week of therapy.
Metoprolol is indicated for the treatment of hypertension, angina chest painand for the treatment or prevention of a heart attack. Patients should be informed about measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning, or rising slowly from a seated position.
Additive reductions in blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents.
The dosage used in these studies ranged from to mg daily.