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Tamoxifen safe handling

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Personal Protective Equipment PPE When working with Tamoxifen in laboratories outside of animal facilities, PPE should include, at a minimum, a lab coat, double Nitrile gloves, and ANSI Z compliant protective eyewear that provides chemical splash protection and appropriate lab attire full-length pants, closed toe shoes, etc.

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Contact the Office of Environmental Health and Safety for more information. Whenever feasible, self-sheathing needles should be used to avoid the potential for accidental needle stick injuries. Cage changes should take place in a cage change cabinet whenever possible. Though it is not carcinogenic or mutagenic, it is still toxic and targets the liver. Mice excrete a much higher amount of 4-hydroxytamoxifen than other species.

II. Toxicity

Animals who have been administered Tamoxifen will not show any visual signs of toxicity after administration. Pregnant women should not be exposed to or handle this chemical in any form. Contact the Office of Environmental Health and Safety prior to purchasing or wearing respiratory protection. Following preparation of Tamoxifen, the work area should be thoroughly cleaned with soap and water. Note that the use of an N95 respirator requires medical clearance and fit testing to comply with 29 CFR It is recommended that animal bedding should be made of material to minimize dust generation, such as Corn-o-Cobs or Alpha pad liners.

Cardboard, paper or other friable materials should be avoided whenever possible. Bedding changes and cage washing should be conducted in an approved cage wash facility that is maintained under negative pressure. Direct contact with the stock solution usually in sesame or corn oil should be avoided.

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The bedding should be disposed of as regulated medical waste and packaged for incineration after any cage changes made within 72 hours post Tamoxifen-administration. Chemical hazard tags noting Tamoxifen and its potential hazards must be kept on the cages for 72 hours following the last administration to the animal.

Used needles must be disposed of in an approved sharps container immediately after use. Because Tamoxifen is a carcinogen, a teratogen and a mutagen, it must be handled carefully. Cages should be changed inside a cage change station or other containment device during the 72 hour period post administration.

A plastic liner which can simply be rolled up and disposed of should be placed under the bedding when cage changes cannot take place in a cage change cabinet. To ensure the safety of research staff, solutions of Tamoxifen should be handled and prepared inside a chemical fume hood that has been approved by the Office of Environmental Health and Safety. When working with Tamoxifen in laboratories outside of animal facilities, PPE should include, at a minimum, a lab coat, double Nitrile gloves, and ANSI Z compliant protective eyewear that provides chemical splash protection and appropriate lab attire full-length pants, closed toe shoes, etc.

Chronic administration of Tamoxifen via IP should follow the same injection procedures as acute administration above. Research Animal Procedures Because Tamoxifen is a carcinogen, a teratogen and a mutagen, it must be handled carefully.

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